Abstract

Three-component condensation of ethyl 1-R-2-phenyl-4,5-dihydro-4,5-dioxo-1H-pyrrole-3-carboxylates, malononitrile, and acyclic enols (acetylacetone, alkyl acetoacetates, and ethyl benzoylacetate) afforded substituted ethyl 9-amino-10-cyano-1-oxo-3-phenyl-8-oxa-2-azaspiro[4.5]deca-3,6,9-triene-4-carboxylates. The products are interesting from the viewpoint of medicinal chemistry.

中文翻译：

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吡咯二酮，丙二腈和无环烯醇的三组分反应

摘要

1-R-2-苯基-4,5-二氢-4,5-二氧杂-1 H-吡咯-3-羧酸乙酯，丙二腈和无环烯醇（乙酰丙酮，乙酰乙酸烷基酯和苯甲酰乙酸乙酯）的三组分缩合反应得到取代的9-氨基-10-氰基-1-氧代-3-氧代-3-苯基-8-氧代-2-氮杂螺[4.5]癸基-3,6,9-三烯-4-羧酸乙酯。从药物化学的角度来看，这些产品很有趣。