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Identification of two core genes in glioblastomas with different isocitrate dehydrogenase mutation status.
Molecular Biology Reports ( IF 2.8 ) Pub Date : 2020-09-11 , DOI: 10.1007/s11033-020-05804-w
Yuduo Guo 1 , Xiang Wang 1 , Weihai Ning 1 , Hongwei Zhang 1 , Chunjiang Yu 1
Affiliation  

Glioblastoma (GBM) is one of the most common malignancies of the central nervous system, and the Isocitrate Dehydrogenase (IDH) mutation status of GBM has been recognized as a critical prognostic indicator. However, the molecular mechanism underlying the GBM with different IDH mutation status is still not unclear. In this study, a total of 353 DEGs including 207 up-regulated and 146 down-regulated were screened from multiple GBM data sets. Moreover, the biological processes and pathways enriched by DEGs were mainly associated with tumor progression, especially invasion and migration. Then, eight hub genes, including SDC4, SERPINE1, TNC, THBS1, COL1A1, CXCL8, TIMP1 and VEGFA, were selected from a PPI network. Finally, core genes, SERPINE1 and TIMP1, were identified from hub genes by survival analysis and sample validation. Overall, in this study, we revealed underlying molecular mechanisms in GBMs with different IDH mutation status and identified core genes that could be potential markers and targets for diagnosis and treatment of GBMs.



中文翻译:

鉴定胶质母细胞瘤中具有不同异柠檬酸脱氢酶突变状态的两个核心基因。

胶质母细胞瘤(GBM)是中枢神经系统最常见的恶性肿瘤之一,GBM的异柠檬酸脱氢酶(IDH)突变状态已被认为是关键的预后指标。但是,具有不同IDH突变状态的GBM的分子机制仍不清楚。在这项研究中,从多个GBM数据集中筛选了353个DEG,包括207个上调和146个下调。此外,DEG丰富的生物学过程和途径主要与肿瘤进展有关,特别是与侵袭和迁移有关。然后,从PPI网络中选择了8个中枢基因,包括SDC4,SERPINE1,TNC,THBS1,COL1A1,CXCL8,TIMP1和VEGFA。最后,通过存活分析和样品验证从集线器基因中鉴定出核心基因SERPINE1和TIMP1。总的来说,在这项研究中

更新日期:2020-09-11
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