Curcumin is a natural active principle with antioxidant, antibacterial and anti-inflammatory properties. Its use is limited by a low water solubility and fast degradation rate, which hinder its bioavailability. To overcome this problem, curcumin can be delivered through a carrier, which protects the drug molecule and enhances its pharmacological effects. The present work proposes a simple one-pot sol–gel synthesis to obtain a hybrid carrier for curcumin delivery. The hybrid consists of a mesostructured matrix of amorphous silica, which stabilizes the carrier, and hexadecyltrimethylammonium (CTA), a surfactant where curcumin is dissolved to increase its water solubility. The carrier was characterized in terms of morphology (FESEM), physicochemical properties (XRD, FTIR, UV spectroscopy) and release capability in pseudo-physiological solutions. Results show that curcumin molecules were entrapped, for the first time, in a silica-surfactant mesostructured hybrid carrier. The hybrid carrier successfully released curcumin in artificial sweat and in a phosphate buffer saline solution, so confirming its efficacy in increasing curcumin water solubility. The proposed drug release mechanism relies on the degradation of the carrier, which involves the concurrent release of silicon. This suggests strong potentialities for topical administration applications, since curcumin is effective against many dermal diseases while silicon is beneficial to the skin.

姜黄素是具有抗氧化，抗菌和抗炎特性的天然活性成分。它的使用受到水溶性低和降解速度快的限制，这阻碍了它的生物利用度。为了克服这个问题，姜黄素可以通过载体递送，该载体保护药物分子并增强其药理作用。本工作提出了一种简单的一锅溶胶-凝胶合成方法，以获得用于姜黄素递送的杂合载体。杂化物由无定形二氧化硅的介孔结构基质（可稳定载体）和十六烷基三甲基铵（CTA）组成，表面活性剂可溶解姜黄素以增加其水溶性。通过形态学（FESEM），理化性质（XRD，FTIR，UV光谱）和假生理溶液中的释放能力对载体进行了表征。结果表明，姜黄素分子首次被包埋在二氧化硅表面活性剂介孔结构杂化载体中。该杂种载体在人工汗液和磷酸盐缓冲盐溶液中成功释放了姜黄素，因此证实了其在增加姜黄素水溶性方面的功效。提出的药物释放机制依赖于载体的降解，这涉及同时释放硅。由于姜黄素对许多皮肤疾病有效，而硅对皮肤有益，因此这表明了局部给药应用的强大潜力。因此证实了其在增加姜黄素水溶性方面的功效。提出的药物释放机制依赖于载体的降解，这涉及同时释放硅。这暗示了局部给药应用的强大潜力，因为姜黄素可有效抵抗多种皮肤疾病，而硅对皮肤有益。因此证实了其在增加姜黄素水溶性方面的功效。提出的药物释放机制依赖于载体的降解，这涉及同时释放硅。这暗示了局部给药应用的强大潜力，因为姜黄素可有效抵抗多种皮肤疾病，而硅对皮肤有益。