In the last twenty years, research using zebrafish as a model organism has increased immensely. With the many advantages that zebrafish offer such as high fecundity, optical transparency, ex vivo development, and genetic tractability, they are well suited to studying developmental processes and the effect of genetic mutations. More recently, zebrafish models have been used to study autophagy. This important protein degradation pathway is needed for cell and tissue homeostasis in a variety of contexts. Correspondingly, its dysregulation has been implicated in multiple diseases including skeletal disorders. In this review, we explore how zebrafish are being used to study autophagy in the context of skeletal development and disease, and the ways these areas are intersecting to help identify potential therapeutic targets for skeletal disorders.

在过去的二十年里，使用斑马鱼作为模式生物的研究大大增加。斑马鱼具有高繁殖力、光学透明度、离体发育和遗传易处理性等诸多优势，非常适合研究发育过程和基因突变的影响。最近，斑马鱼模型已被用于研究自噬。在各种情况下，细胞和组织稳态需要这种重要的蛋白质降解途径。相应地，它的失调与包括骨骼疾病在内的多种疾病有关。在这篇综述中，我们探讨了斑马鱼如何被用于研究骨骼发育和疾病背景下的自噬，以及这些领域如何交叉以帮助确定骨骼疾病的潜在治疗靶点。