Atherosclerotic plaque in the femoral is the leading cause of peripheral artery disease (PAD), the worse consequence of which may lead to ulceration and gangrene of the feet. Numerical studies on fluid-structure interactions (FSI) of atherosclerotic femoral arteries enable quantitative analysis of biomechanical features in arteries. This study aims to investigate the hemodynamic performance and its interaction with femoral arterial wall based on the patient-specific model with multiple plaques (calcified and lipid plaques). Three types of models, calcification-only, lipid-only and calcification-lipid models, are established. Hyperelastic material coefficients of the human femoral arteries obtained from experimental studies are employed for all simulations. Oscillation of WSS is observed in the healthy downstream region in the lipid-only model. The pressure around the plaques in the two-plaque model is lower than that in the corresponding one-plaque models due to the reduction of blood flow domain, which consequently diminishes the loading forces on both plaques. Therefore, we found that stress acting on the plaques in the two-plaque model is lower than that in the corresponding one-plaque models. This finding implies that the lipid plaque, accompanied by the calcified plaque around, might reduce its risk of rupture due to the reduced the stress acting on it.

股骨中的动脉粥样硬化斑块是外周动脉疾病 (PAD) 的主要原因，其更严重的后果可能导致足部溃疡和坏疽。对动脉粥样硬化股动脉的流体-结构相互作用 (FSI) 进行数值研究，可以对动脉中的生物力学特征进行定量分析。本研究旨在基于具有多个斑块（钙化斑块和脂质斑块）的患者特异性模型，研究血流动力学性能及其与股动脉壁的相互作用。建立了三种类型的模型，仅钙化模型、仅脂质模型和钙化脂质模型。从实验研究中获得的人类股动脉的超弹性材料系数用于所有模拟。在纯脂质模型的健康下游区域中观察到 WSS 的振荡。由于血流域的减少，双斑块模型中斑块周围的压力低于相应的单斑块模型，从而减少了两个斑块上的加载力。因此，我们发现两斑块模型中作用在斑块上的应力低于相应的一斑块模型中的应力。这一发现意味着脂质斑块，伴随着周围的钙化斑块，可能会降低其破裂的风险，因为作用在它上面的应力减少了。我们发现在两斑块模型中作用在斑块上的应力低于相应的一斑块模型中的应力。这一发现意味着脂质斑块，伴随着周围的钙化斑块，可能会降低其破裂的风险，因为作用在它上面的应力减少了。我们发现在两斑块模型中作用在斑块上的应力低于相应的一斑块模型中的应力。这一发现意味着脂质斑块，伴随着周围的钙化斑块，可能会降低其破裂的风险，因为作用在它上面的应力减少了。