ABSTRACT

Objectives

The objective of our study is to evaluate the impact of neurosurgical operative treatment on the performance status assessed by the Karnofsky Performance Scale (KPS) in patients with HGG for the first, for the second intervention and for the different age groups.

Methods

A group of 425 patients operated consecutively for high-grade gliomas were included in this study. The performance status was evaluated preoperatively and 15 days postoperatively with the KPS. Analyses for the different histological grade, tumor locations and age groups divided by decades have been made.

Results

The initial, preoperative KPS score for patients with grade III tumor was 77.65 and for grade IV – 71.35. Following the first operation mean KPS has a statistically significant increase and reaches 82.24 and 78.41, respectively. The improvement of the performance status after the first operation was significant for all relevant age groups, including the sixth, seventh and eighth decades. Although the obtained mean KPS scores after the second operation did not show improvement there was also no clear evidence for worsening in this group of patients (n = 100) and the negative results obtained were not statistically significant.

Conclusion

According to our study, the first operation has a beneficial effect on the performance status in patients with HGG. The results for the second operation are more ambiguous, but there is no clear evidence for worsening of the KPS score after the second intervention. These results were relevant for all age groups, so we may expect amelioration in the performance status even in older patients.

中文翻译：

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手术治疗对高级别胶质瘤患者体能状态的影响。

摘要

目标

我们研究的目的是评估神经外科手术治疗对第一次、第二次干预和不同年龄组 HGG 患者的 Karnofsky 体能量表 (KPS) 评估的体能状态的影响。

方法

本研究包括一组 425 名连续手术的高级别胶质瘤患者。使用 KPS 评估术前和术后 15 天的体能状态。已经对不同的组织学分级、肿瘤位置和年龄组进行了分析。

结果

III 级肿瘤患者的初始术前 KPS 评分为 77.65，IV 级为 71.35。第一次操作后，KPS 均值在统计上显着增加，分别达到 82.24 和 78.41。对于所有相关年龄组，包括 60、7 和 80 岁，第一次手术后体能状态的改善都是显着的。虽然在第二次手术后获得的平均 KPS 评分没有显示出改善，但也没有明确的证据表明这组患者（n = 100）恶化并且获得的阴性结果没有统计学意义。

结论

根据我们的研究，首次手术对 HGG 患者的体能状态有有益影响。第二次手术的结果更加模糊，但没有明确证据表明第二次干预后KPS评分恶化。这些结果适用于所有年龄组，因此我们可以预期即使是老年患者的体能状态也会有所改善。