Neurons and glia are functionally organized into circuits and higher-order structures that allow the precise information processing required for complex behaviors. To better understand the structure and function of the brain, we must understand synaptic connectivity, action potential generation and propagation, as well as well-orchestrated molecular signaling. Recently, dramatically improved sensors for voltage, intracellular calcium, and neurotransmitters/modulators, combined with advanced microscopy provide new opportunities for in vivo dissection of cellular and circuit activity in awake, behaving animals. This review focuses on the current trends in genetically encoded sensors for molecules and cellular events and their potential applicability to the study of nervous system in health and disease.

中文翻译：

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使用遗传编码的传感器和调节器对电压和大脑化学物质进行成像。

神经元和神经胶质细胞在功能上组织为电路和高阶结构，可进行复杂行为所需的精确信息处理。为了更好地了解大脑的结构和功能，我们必须了解突触的连通性，动作电位的产生和传播以及精心设计的分子信号传导。最近，大大改进的电压，细胞内钙和神经递质/调节剂传感器，与先进的显微镜技术相结合，为清醒，表现良好的动物体内解剖细胞和电路活动提供了新的机会。这篇综述着重于分子和细胞事件的遗传编码传感器的当前趋势及其在健康和疾病中神经系统研究中的潜在适用性。