PURPOSE New biomarkers are emerging to predict recurrence risk in women with early-stage breast cancer. High Oncotype DX Recurrence Score® (RS) is associated with worse disease-free and overall survival. Similarly, circulating tumor cells (CTCs, blood) and disseminated tumor cells (DTCs, bone marrow) have prognostic value in breast cancer. We investigated the association between high RS and CTCs or DTCs. METHODS Using a prospective database, we evaluated patients with hormone receptor-positive/HER2-negative, node-negative invasive breast cancer from 1/2005 to 1/2017. RS was classified using TAILORx study cutoff points: low (< 11), intermediate (11-25), and high (> 25). CTCs were assessed using CellSearch® and DTCs using cytospin specimens of bone marrow aspirates. Positive result was defined as one or more CTCs or DTCs identified. Chi-square analyses were utilized to evaluate the relationship between RS and CTCs or DTCs. RESULTS 233 patients were identified from a prospective database, of which 96 had RS results. Of these patients, 88 had CTC results and 58 had DTC results. CTCs were detected in 17/88 (19%) patients, while DTCs were detected in 20/58 (34%). Patients with high RS were not more likely to have CTCs (18%) compared to patients with low/intermediate RS (20%; p = 0.919). Similarly, high RS was not associated with DTC detection, with DTCs present in 40% of patients with high RS versus 33% with low/intermediate RS (p = 0.687). In the subgroup of patients ≤ 50 years, no associations were found between high RS and CTCs (p = 0.383) or DTCs (p = 0.234). CONCLUSIONS High Oncotype DX RS did not correlate with CTCs in blood or DTCs in bone marrow in our study.

中文翻译：

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循环或播散的肿瘤细胞与 Oncotype DX 复发评分的相关性。

目的 正在出现新的生物标志物来预测早期乳腺癌女性的复发风险。高 Oncotype DX Recurrence Score® (RS) 与较差的无病生存率和总生存率相关。同样，循环肿瘤细胞（CTC、血液）和播散性肿瘤细胞（DTC、骨髓）在乳腺癌中具有预后价值。我们调查了高 RS 与 CTC 或 DTC 之间的关联。方法使用前瞻性数据库，我们评估了 2005 年 1/2017 年至 1/2017 年间激素受体阳性/HER2 阴性、淋巴结阴性的浸润性乳腺癌患者。RS 使用 TAILORx 研究截止点进行分类：低 (< 11)、中 (11-25) 和高 (> 25)。使用 CellSearch® 和 DTC 使用骨髓抽吸物的 cytospin 样本评估 CTC。阳性结果定义为鉴定出一种或多种 CTC 或 DTC。卡方分析用于评估 RS 与 CTC 或 DTC 之间的关系。结果 从前瞻性数据库中确定了 233 名患者，其中 96 名具有 RS 结果。在这些患者中，88 名有 CTC 结果，58 名有 DTC 结果。在 17/88 (19%) 患者中检测到 CTC，而在 20/58 (34%) 中检测到 DTC。与低/中 RS 患者 (20%；p = 0.919) 相比，高 RS 患者不太可能有 CTC (18%)。同样，高 RS 与 DTC 检测无关，40% 的高 RS 患者存在 DTC，而 33% 的低/中 RS 患者存在 DTC（p = 0.687）。在≤ 50 岁的患者亚组中，未发现高 RS 与 CTC (p = 0.383) 或 DTC (p = 0.234) 之间存在关联。结论 在我们的研究中，高 Oncotype DX RS 与血液中的 CTC 或骨髓中的 DTC 无关。