Black women contract HIV at much higher rates than White or Hispanic women. Pre-exposure prophylaxis (PrEP) is an underutilized prevention tool among this population. We sought to determine participants’ interest in PrEP and facilitators and barriers to PrEP adoption. This longitudinal, qualitative study included 30 Black women (M_age = 32.2) interviewed 4 times over 6 months. Most participants had never heard of PrEP and a majority expressed initial interest. Barriers to PrEP initiation included low perceived HIV risk, medical mistrust, provider experiences and knowledge, negative reactions from family and friends, low perceived efficacy to adherence, and transportation. This study demonstrated actual, rather than hypothetical, PrEP interest and attitudes among Black women, and the barriers that arose over time during the study. PrEP awareness needs to be promoted among Black women and medical providers. Future research should address individual risk perception, medical mistrust, increasing social support, and decreasing transportation barriers.

与白人或西班牙裔女性相比，黑人女性感染 HIV 的几率要高得多。暴露前预防 (PrEP) 是该人群中未被充分利用的预防工具。我们试图确定参与者对 PrEP 和促进者的兴趣以及采用 PrEP 的障碍。这项纵向、定性研究包括 30 名黑人女性（M_年龄 = 32.2) 在 6 个月内接受了 4 次采访。大多数参与者从未听说过 PrEP，大多数参与者表示最初感兴趣。PrEP 启动的障碍包括低感知的 HIV 风险、医疗不信任、提供者的经验和知识、家人和朋友的负面反应、对依从性的感知效率低和交通。这项研究展示了黑人女性对 PrEP 的兴趣和态度，以及研究期间随着时间的推移而出现的障碍，而不是假设的。需要在黑人女性和医疗服务提供者中提高 PrEP 意识。未来的研究应该解决个人风险感知、医疗不信任、增加社会支持和减少交通障碍。