In this paper, we developed a novel strategy of preparing doxorubicin (DOX) nanocrystal (NC) exerting spherical particles with a diameter of 102 nm, which experienced following coating of chondroitin sulphate derivative (CSOA) shell via electrostatic and hydrophobic interactions. Such multifunctional outerwear resulted in drug nanocapsules with high drug loading content up to 70% and high colloidal stability under physiological conditions. It exhibited accelerated drug release behaviour when dispersing in hyaluronidase (HAase) containing medium or incubated with cancer cells. CSOA/NCs were effectively taken up by cancer cells via CD44 receptor-mediated endocytosis, but were rarely internalised into normal fibroblasts. With the comparison of typical drug-loaded micelles system (DOX/PEG-PCL), CSOA/NCs showed greater inhibition to cancer cells due to the targeted and sensitive drug delivery.

中文翻译：

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硫酸软骨素修饰的阿霉素纳米晶体的酶/ pH触发抗癌药物传递。

在本文中，我们开发了一种制备直径为102 nm的球形颗粒的阿霉素（DOX）纳米晶体（NC）的新策略，该过程通过静电和疏水相互作用涂覆了硫酸软骨素衍生物（CSOA）外壳。这种多功能外衣导致药物纳米胶囊具有高达70％的高载药量和在生理条件下的高胶体稳定性。当分散在含有透明质酸酶（HAase）的培养基中或与癌细胞一起孵育时，它表现出加速的药物释放行为。CSOA / NCs通过CD44受体介导的内吞作用被癌细胞有效吸收，但很少内化到正常的成纤维细胞中。通过比较典型的载药胶束系统（DOX / PEG-PCL），