This review summarizes the recent progress in research on the non-heme Fe(II)- and 2-oxoglutarate-dependent dioxygenases, which are involved in the biosynthesis of pharmaceutically important fungal meroterpenoids. This enzyme class activates a selective C–H bond of the substrate and catalyzes a wide range of chemical reactions, from simple hydroxylation to dynamic carbon skeletal rearrangements, thereby significantly contributing to the structural diversification and complexification of the molecules. Structure–function studies of these enzymes provide an excellent platform for the development of useful biocatalysts for synthetic biology to create novel molecules for future drug discovery.

这篇综述总结了非血红素依赖于Fe（II）和2-氧戊二酸酯的双加氧酶的最新研究进展，这些酶参与了重要的药用真菌类萜的生物合成。该酶类别激活底物的选择性C–H键并催化从简单的羟基化到动态碳骨架重排的广泛化学反应，从而显着促进了分子的结构多样化和复杂化。这些酶的结构-功能研究为开发有用的生物合成生物催化剂提供了一个极好的平台，可以为未来的药物开发创造新的分子。