Asthma is an obstructive inflammatory airway disease. Airway obstruction is mediated by hyperresponsive airway smooth muscle cell contraction, which is induced and compounded by inflammation caused by T lymphocytes. One important signal transduction pathway that is involved in the activation of these cell types involves the generation of a lipid second messenger known as diacylglycerol (DAG). DAG levels are controlled in cells by a negative regulator known as DAG kinase (DGK). In this review, we discuss how the DAG signaling pathway attenuates the pathological function of immune cells and airway smooth muscle cells in allergic airway disease and asthma. Furthermore, we discuss how the enhancement of the DAG signaling pathway through the inhibition of DGK may represent a novel therapeutic strategy for these diseases.

中文翻译：

---

二酰基甘油激酶在过敏性气道疾病中的作用。

哮喘是一种阻塞性炎症性气道疾病。气道阻塞由高反应性气道平滑肌细胞收缩介导，由 T 淋巴细胞引起的炎症诱导和复合。参与激活这些细胞类型的一个重要信号转导途径涉及生成称为二酰基甘油 (DAG) 的脂质第二信使。细胞中的 DAG 水平由称为 DAG 激酶 (DGK) 的负调节因子控制。在这篇综述中，我们讨论了 DAG 信号通路如何减弱免疫细胞和气道平滑肌细胞在过敏性气道疾病和哮喘中的病理功能。此外，我们讨论了如何通过抑制 DGK 来增强 DAG 信号通路可能代表这些疾病的新治疗策略。