Food insecurity (FI), low social support, and low health-related quality of life (HRQoL) are associated with self-reported nonadherence to antiretroviral therapy (ART) among postpartum women, but these relationships have not been evaluated using objective adherence indicators. Hair samples were therefore analyzed among 83 postpartum Kenyan women living with HIV on efavirenz and nevirapine ART drug regimens in an observational cohort (NCT02974972). FI (0-27), social support (0-40), and HRQoL (8-40) in the prior month were also assessed. In multivariable models, each point increase in FI and decrease in HRQoL were associated with a 45.1% (95% CI: -64.3%, -15.6%) and 10.5% decrease (95% CI: 1.0%, 22.1%) in hair ART drug concentrations respectively, when social support was held constant. A significant interaction between social support and FI (β = 0.02, p = 0.017) indicated that greater social support was predicted to mitigate the negative impacts of FI on ART adherence. Addressing these modifiable barriers could improve ART adherence during this critical period.

中文翻译：

---

社会支持减轻粮食不安全对肯尼亚西部产后妇女抗逆转录病毒治疗依从性的负面影响。

粮食不安全（FI）、低社会支持和低健康相关生活质量（HRQoL）与产后妇女自我报告的不遵守抗逆转录病毒治疗（ART）有关，但这些关系尚未使用客观的依从性指标进行评估。因此，我们对观察队列中 83 名使用依非韦伦和奈韦拉平 ART 药物治疗方案的产后感染艾滋病毒的肯尼亚妇女的头发样本进行了分析 (NCT02974972)。还评估了上个月的 FI (0-27)、社会支持 (0-40) 和 HRQoL (8-40)。在多变量模型中，FI 的每一点增加和 HRQoL 的降低与头发 ART 的 45.1%（95% CI：-64.3%，-15.6%）和 10.5% 的降低（95% CI：1.0%，22.1%）相关当社会支持保持不变时，药物浓度分别。社会支持和 FI 之间的显着交互作用（β = 0.02，p = 0.017）表明，预计更大的社会支持可以减轻 FI 对 ART 依从性的负面影响。解决这些可改变的障碍可以提高这一关键时期的 ART 依从性。