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Phaeohyphomycosis: Cytomorphologic Evaluation in Eleven Cases.
Acta Cytologica ( IF 1.8 ) Pub Date : 2020-03-23 , DOI: 10.1159/000506432
Reetu Kundu 1 , Uma Handa 2 , Rajpal Singh Punia 2 , Nidhi Singla 2 , Jagdish Chander 2 , Ashok Kumar Attri 2
Affiliation  

OBJECTIVE Phaeohyphomycosis caused by phaeoid fungi is a type of mycosis emerging worldwide which causes a wide variety of clinical manifestations. STUDY DESIGN A retrospective analysis of 11 cases diagnosed with fungal inflammation on cytology over a period of 6 years (2013-2018) was done along with culture/histopathologic confirmation. RESULTS Of the total of 11 cases, 9 cases presented with subcutaneous swellings and 1 case each with brain and lung lesions. The age range was 30-83 years (mean: 53.6); 8 patients were male and 3 were female. Cytologic smears showed fungal profiles with septate tortuous hyphae, as well as swollen and narrow, yeast-like swellings with an irregular breadth of the hyphae in all cases. The fungal profiles were visualized on a Masson-Fontana stain. The background showed inflammatory cells, giant cells, and necrosis in variable proportions. Five cases were diagnosed as phaeohyphomycosis on cytology, whereas 3 cases were misdiagnosed as aspergillus and 2 as candida. In 1 case, typing of the fungus was not done. Histopathology was available in 5 cases, and in all these a diagnosis of phaeohyphomycosis was reached. Ten of the 11 cases had confirmation on fungal culture. CONCLUSIONS Phaeoid fungi are rarely seen in routine cytologic practice. Careful evaluation of cytologic smears and an awareness of the characteristic morphologic features of phaeohyphomycosis are helpful in arriving at a correct diagnosis. Fine needle aspiration cytology provides a rapid diagnosis, enabling prompt therapy.

中文翻译:

血小板萎缩症:11例的细胞形态学评估。

目的蝶形真菌引起的腐菌病是一种在世界范围内出现的真菌病,引起多种临床表现。研究设计对6年来(2013-2018年)经细胞学诊断为真菌性炎症的11例病例进行回顾性分析,并进行文化/组织病理学确认。结果在11例患者中,有9例出现皮下肿胀,其中1例出现脑部和肺部病变。年龄范围为30-83岁(平均53.6);男性8例,女性3例。在所有情况下,细胞学涂片均显示真菌特征,具有分隔的曲折菌丝,以及肿胀和狭窄的类似酵母的肿胀,菌丝宽度不规则。在Masson-Fontana染色剂上可视化真菌轮廓。背景显示炎症细胞,巨细胞,和坏死的比例不同。细胞学诊断为滋生真菌病5例,曲霉菌3例,曲霉菌2例。在1种情况下,未进行真菌分型。有5例可以进行组织病理学检查,所有这些都可以诊断为睑板真菌病。11例病例中有10例证实了真菌培养。结论类真菌在常规细胞学实践中很少见。仔细评估细胞学涂片和了解咽下真菌病的特征形态特征有助于正确诊断。细针穿刺细胞学检查可快速诊断,并迅速进行治疗。真菌的打字没有完成。有5例可进行组织病理学检查,所有这些都可诊断为睑板真菌病。11例病例中有10例证实了真菌培养。结论类真菌在常规细胞学实践中很少见。仔细评估细胞学涂片和了解咽下真菌病的特征形态特征有助于正确诊断。细针穿刺细胞学检查可快速诊断,并迅速进行治疗。真菌的打字没有完成。有5例可以进行组织病理学检查,所有这些都可以诊断为睑板真菌病。11例病例中有10例证实了真菌培养。结论类真菌在常规细胞学实践中很少见。仔细评估细胞学涂片和了解咽下真菌病的特征形态特征有助于正确诊断。细针穿刺细胞学检查可快速诊断,并迅速进行治疗。仔细评估细胞学涂片和了解咽下真菌病的特征形态特征有助于正确诊断。细针穿刺细胞学检查可快速诊断,并迅速进行治疗。仔细评估细胞学涂片和了解咽下真菌病的特征形态特征有助于正确诊断。细针穿刺细胞学检查可快速诊断,并迅速进行治疗。
更新日期:2020-03-23
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