Administration of substances through the skin represents a promising alternative, in relation to other drug administration routes, due to its large body surface area, in order to offer ideal and multiple sites for drug administration. In addition, the administration of drugs through the skin avoids the first-pass metabolism, allowing an increase in the bioavailability of drugs, as well as reducing their side effects. However, the stratum corneum (SC) comprises the main barrier of protection against external agents, mainly due to its structure, composition and physicochemical properties, becoming the main limitation for the administration of substances through the skin. In view of the above, pharmaceutical technology has allowed the development of multiple drug delivery systems (DDS), which include liquid crystals (LC), cubosomes, liposomes, polymeric nanoparticles (PNP), nanoemulsions (NE), as well as cyclodextrins (CD) and dendrimers (DND). It appears that the DDS circumvents the problems of drug absorption through the SC layer of the skin, ensuring the release of the drug, as well as optimizing the therapeutic effect locally. This review aims to highlight the DDS that include LC, cubosomes, lipid systems, PNP, as well as CD and DND, to optimize topical skin therapies.

与其他药物给药途径相比，通过皮肤给药是一种有前景的替代方案，因为它具有较大的体表面积，以便为给药提供理想的多个部位。此外，通过皮肤给药可避免首过代谢，从而提高药物的生物利用度，并减少其副作用。然而，角质层 (SC) 是抵御外部因素的主要屏障，这主要是由于其结构、组成和理化性质，成为通过皮肤施用物质的主要限制。综上所述，制药技术允许开发多种药物递送系统（DDS），包括液晶（LC）、立方体、脂质体、聚合物纳米粒子（PNP），纳米乳液（NE）以及环糊精（CD）和树状聚合物（DND）。看来DDS规避了药物通过皮肤SC层吸收的问题，确保了药物的释放，同时优化了局部的治疗效果。本综述旨在突出包括 LC、立方体、脂质系统、PNP 以及 CD 和 DND 的 DDS，以优化局部皮肤治疗。