Pluripotent stem cells differentiate with varying efficiencies depending on the method of reprogramming that created them. In this issue, Paniza et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201909163) demonstrate that cells with lower differentiation potential retain some features of somatic DNA replication origin utilization and suffer more frequent DNA damage.

中文翻译：

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多能干细胞编程：无法教会老细胞新的DNA复制技巧

多能干细胞的分化效率不同，具体取决于产生它们的重编程方法。在本期中，Paniza 等人。(2020. J. Cell Biol.https://doi.org/10.1083/jcb.201909163) 证明，分化潜力较低的细胞保留了体细胞 DNA 复制起点利用的一些特征，并遭受更频繁的 DNA 损伤。