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Histone Variants: The Nexus of Developmental Decisions and Epigenetic Memory.
Annual Review of Genetics ( IF 11.1 ) Pub Date : 2020-11-23 , DOI: 10.1146/annurev-genet-022620-100039
Benjamin Loppin 1 , Frédéric Berger 2
Affiliation  

Nucleosome dynamics and properties are central to all forms of genomic activities. Among the core histones, H3 variants play a pivotal role in modulating nucleosome structure and function. Here, we focus on the impact of H3 variants on various facets of development. The deposition of the replicative H3 variant following DNA replication is essential for the transmission of the epigenomic information encoded in posttranscriptional modifications. Through this process, replicative H3 maintains cell fate while, in contrast, the replacement H3.3 variant opposes cell differentiation during early embryogenesis. In later steps of development, H3.3 and specialized H3 variants are emerging as new, important regulators of terminal cell differentiation, including neurons and gametes. The specific pathways that regulate the dynamics of the deposition of H3.3 are paramount during reprogramming events that drive zygotic activation and the initiation of a new cycle of development.

中文翻译:


组蛋白变体:发展决策与表观遗传记忆的结合。

核小体的动力学和特性对于所有形式的基因组活动都是至关重要的。在核心组蛋白中,H3变体在调节核小体结构和功能中起关键作用。在这里,我们重点介绍H3变体对发展各个方面的影响。DNA复制后复制性H3变体的沉积对于转录后修饰中编码的表观基因组信息的传递至关重要。通过此过程,复制性H3维持了细胞命运,与此相反,替代H3.3变体在早期胚胎发生过程中反对细胞分化。在后续的开发步骤中,H3.3和专门的H3变体作为终端细胞分化(包括神经元和配子)的新的重要调节剂出现。调节H3沉积动力学的特定途径。

更新日期:2020-11-25
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