The Ontario Neurodegenerative Research Initiative (ONDRI) is a 3 years multi-site prospective cohort study that has acquired comprehensive multiple assessment platform data, including 3T structural MRI, from neurodegenerative patients with Alzheimer's disease, mild cognitive impairment, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, and cerebrovascular disease. This heterogeneous cross-section of patients with complex neurodegenerative and neurovascular pathologies pose significant challenges for standard neuroimaging tools. To effectively quantify regional measures of normal and pathological brain tissue volumes, the ONDRI neuroimaging platform implemented a semi-automated MRI processing pipeline that was able to address many of the challenges resulting from this heterogeneity. The purpose of this paper is to serve as a reference and conceptual overview of the comprehensive neuroimaging pipeline used to generate regional brain tissue volumes and neurovascular marker data that will be made publicly available online.

中文翻译：

---

安大略省神经退行性疾病研究计划（ONDRI）：结构MRI方法和结果测量。

安大略省神经退行性研究计划（ONDRI）是一项为期3年的多站点前瞻性队列研究，已从患有阿尔茨海默氏病，轻度认知障碍，帕金森氏病，肌萎缩性侧索硬化症，额颞叶性痴呆和脑血管疾病。具有复杂的神经退行性病变和神经血管病变的患者的这种异质截面对标准的神经成像工具提出了重大挑战。为了有效量化正常和病理性脑组织体积的区域测量，ONDRI神经成像平台实施了半自动MRI处理管道，该管道能够解决这种异质性带来的许多挑战。