Animal experiment findings suggest that high doses of ionizing radiation exposure (>1.0 Gy) may cause genetic and epigenetic effects in offspring. However, epidemiological studies of offspring of radiation-exposed parents did not find increased risks of any health effects. Findings of cellular/experimental investigations and studies of human health effects are contradicting, and further investigations are needed to help resolve ambiguities using updated and/or improved data. This paper provides a detailed description of a database of families of workers of the first Russian nuclear facility, Mayak Production Association, located in the Southern Urals in the Chelyabinsk region close to Ozyorsk city, which started its operation in 1948 and today consists of reactors, radiochemical and plutonium production plants, and auxiliary facilities. The Mayak worker cohort includes 22,377 individuals (25% females) who were hired at one of the main Mayak PA facilities between 1948 and 1982 and were externally or internally exposed to ionizing radiation over prolonged periods. Advantages of the cohort include its large size, extensive follow-up period (70 y), individually measured doses from external and internal exposure and the wide range of these doses, heterogeneity by gender/age/ethnicity/initial health status, complete data on vital status and causes of death, available medical information on morbidity and reproduction, available data on non-radiation factors, and stored biological specimens donated by more than one-third of the cohort members. Based on medical and dosimetry database "Clinics" containing raw data on workers of the study cohort, the Mayak workers' family and offspring database was created. To date, it comprises 12,195 family couples (a husband and a wife) and 16,585 offspring. Biological specimens are available for more than 1,000 family triads (a husband, a wife, and their child). Stages of assembling the database and its descriptive characteristics are presented in this paper. Examples of potential applications of the database for investigations of non-targeted and transgenerational radiation effects in offspring of exposed parents are discussed.

中文翻译：

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长期暴露于辐射的工人家庭数据库：数据和生物样本资源。

动物实验结果表明，高剂量的电离辐射暴露（>1.0 Gy）可能会对后代造成遗传和表观遗传效应。然而，对暴露于辐射的父母的后代的流行病学研究没有发现任何健康影响的风险增加。细胞/实验调查和人类健康影响研究的结果相互矛盾，需要进一步调查以帮助使用更新和/或改进的数据解决歧义。本文详细介绍了俄罗斯第一座核设施 Mayak Production Association 工人家属数据库，该设施位于靠近 Ozyorsk 市的车里雅宾斯克地区南部乌拉尔地区，该设施于 1948 年开始运行，如今由反应堆组成，放射化学和钚生产厂和辅助设施。Mayak 工人群体包括 22,377 人（25% 为女性），她们在 1948 年至 1982 年期间受雇于 Mayak PA 的主要设施之一，并在外部或内部长时间暴露于电离辐射。该队列的优势包括规模大、随访时间长（70 年）、单独测量的外照射和内照射剂量以及这些剂量的范围广、性别/年龄/种族/初始健康状况的异质性、完整的数据生命状况和死亡原因、关于发病率和繁殖的可用医学信息、关于非辐射因素的可用数据以及超过三分之一的队列成员捐赠的储存生物标本。基于包含研究队列工人原始数据的医学和剂量学数据库“诊所”，Mayak 工人的 创建了家庭和后代数据库。迄今为止，它包括 12,195 对家庭夫妇（丈夫和妻子）和 16,585 名后代。生物标本可用于 1,000 多个家庭三合会（丈夫、妻子和他们的孩子）。本文介绍了组装数据库的阶段及其描述性特征。讨论了该数据库在调查暴露父母后代的非靶向和跨代辐射效应方面的潜在应用示例。