Minimizing cognitive side effects of electroconvulsive therapy (ECT) while maintaining clinical efficacy is a key challenge. Given that the electrical charge required to induce a seizure varies by as much as 30-fold among patients [1], and that clinical efficacy and side effects of ECT depend strongly on the dose applied relative to the individual seizure threshold [2], many providers have adopted routine seizure threshold determination at the time of first treatment. As these protocols are not standardized, and likely vary based on the ECT electrode placement and stimulus parameters, information about the typical seizure threshold would help guide clinical practice. This study quantifies the charge required to induce a seizure using right unilateral brief pulse (RUL-BP) ECT in a large retrospective cohort.

中文翻译：

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使用右侧单侧短脉冲电惊厥疗法进行初始剂量滴定期间诱发癫痫发作所需的电荷

在保持临床疗效的同时最大限度地减少电休克疗法 (ECT) 的认知副作用是一项关键挑战。鉴于诱发癫痫发作所需的电荷在患者中的差异高达 30 倍 [1]，并且 ECT 的临床疗效和副作用在很大程度上取决于相对于个体癫痫发作阈值的应用剂量 [2]，许多提供者在第一次治疗时采用了常规的癫痫发作阈值确定。由于这些协议未标准化，并且可能因 ECT 电极放置和刺激参数而异，因此有关典型癫痫发作阈值的信息将有助于指导临床实践。本研究在大型回顾性队列中量化了使用右单侧短脉冲 (RUL-BP) ECT 诱发癫痫发作所需的电荷。