Different environmental toxins especially heavy metals exist in soil, water, and air recording toxic effect on human, animal, and plant. These toxicant elements are widespread in environment causing various disturbances in biological systems. Numerous strategies have been applied recently to alleviate heavy metal contamination; however, most of these strategies were costly and seemed unfriendly to our environment. Probiotics are living cell bacteria with beneficial characteristics for human health. Lactobacillus and Bifidobacterium are the major probiotic groups; however, Pediococcus, Lactococcus, Bacillus, and yeasts are recorded as probiotic. The vital role of the probiotics on maintenance of body health was previously investigated. Probiotics were previously recorded to its powerful capacity to bind numerous targets and eliminate them with feces. These targets may be aluminum, cadmium, lead, or arsenic. The current review discusses the history of probiotics, detoxification role of probiotics caused by heavy metals, and mechanism of their action that modulate different signaling pathway disturbance associated with heavy metal accumulation in biological system.

土壤，水和空气中存在不同的环境毒素，尤其是重金属，记录了对人类，动物和植物的毒性作用。这些有毒元素广泛存在于环境中，导致生物系统受到各种干扰。最近已经采用了许多策略来减轻重金属的污染。但是，这些策略大多数都很昂贵，而且似乎对我们的环境不友好。益生菌是对人体健康有益的活细胞细菌。乳酸菌和双歧杆菌是主要的益生菌。但是，小球菌，乳球菌，芽孢杆菌和酵母菌被记录为益生菌。以前已经研究了益生菌在维持身体健康中的重要作用。以前已经记录了益生菌的强大功能，可以结合许多靶标并通过粪便消除它们。这些目标可能是铝，镉，铅或砷。本篇综述讨论了益生菌的历史，益生菌对重金属的排毒作用，以及它们调节与生物系统中重金属积累相关的不同信号通路干扰的作用机理。