Biological Trace Element Research ( IF 3.9 ) Pub Date : 2020-08-20 , DOI: 10.1007/s12011-020-02331-4 Hantong Zhao 1 , Yingan Pan 1 , Changcong Wang 1 , Yinpei Guo 1 , Nan Yao 1 , Han Wang 1 , Bo Li 1
Background
With the rising incidence of chronic diseases, and the increase of aging population has led to multimorbidity a serious public health problem. The aim of this study was to explore the association between metal exposures and Charlson comorbidity index (CCI), which will provide valuable information for improving quality of life and reducing mortality.
Methods
The study sample consists of three continuous cycles (2011–2016) of the National Health and Nutrition Examination Survey (NHANES), and 4901 eligible subjects were included in the study. Zero-inflated negative binomial (ZINB) model was utilized to investigate the effects in metal exposures on CCI, which includes spot urine (arsenic, mercury, and cadmium), whole blood (manganese, selenium, and lead), and serum (copper and zinc).
Results
In count part (CCI ≥ 0), holding other variables constant, the expected change in CCI for a one-unit increase in blood selenium is 0.997 (RR = 0.997, p = 0.017). In logit part (CCI = 0), the log odds of having CCI equals zero would increase by 0.659, 1.073, and 0.963 for every additional urinary cadmium (OR = 0.659, p = 0.007), blood lead (OR = 1.073, p = 0.023), blood manganese (OR = 0.963, p = 0.025), respectively.
Conclusions
Our findings indicated that cadmium and manganese were likely to increase mortality. Inversely, selenium and lead might be positive on people’s health. The findings may be extremely essential for preventing diseases and improving life quality.
中文翻译:
零膨胀负二项式回归模型对金属暴露对查尔森合并症指数的影响:NHANES 2011–2016
背景
随着慢性病发病率的上升和人口老龄化的增加,导致多发病是一个严重的公共卫生问题。这项研究的目的是探索金属暴露与Charlson合并症指数(CCI)之间的关联,这将为改善生活质量和降低死亡率提供有价值的信息。
方法
该研究样本由国家健康与营养检查调查(NHANES)的三个连续周期(2011-2016)组成,该研究纳入了4901名合格受试者。零膨胀负二项式(ZINB)模型用于研究金属暴露对CCI的影响,包括点尿(砷,汞和镉),全血(锰,硒和铅)和血清(铜和铜)。锌)。
结果
在计数部分(CCI≥0)中,在保持其他变量不变的情况下,血液中硒含量每增加一单位,CCI的预期变化为0.997(RR = 0.997,p = 0.017)。在logit部分(CCI = 0),对于每增加一个尿镉(OR = 0.659,p = 0.007),血铅(OR = 1.073,p = 0.023),血锰(OR = 0.963,p = 0.025)。
结论
我们的发现表明,镉和锰可能会增加死亡率。相反,硒和铅可能对人们的健康有益。该发现对于预防疾病和改善生活质量可能是至关重要的。