Super-hydrophobicity is a well-known and studied phenomenon in the field of surface sciences. In this review we report a novel approach that exploits micro-fabricated super-hydrophobic surfaces for the oriented and self-organized deposition and suspension of DNA filaments and other macromolecules of biological interest. The self-assembled structures obtained with this approach can be used for the characterization of the biological compounds with several methods such as electron microscopy, X-ray diffraction, Raman and SERS spectroscopies. Besides imaging, the described method has been applied in several fields such as the sensing of few molecules in diluted solutions and innovative templating growth. We will focus in particular on the direct imaging of DNA molecules by Transmission Electron Microscopy with the capability to resolve structural details of the double helix down to a resolution of 1.5 Å. The review starts with a brief historical note on the discovery of the DNA structure and continues with the results obtained by our group along the last 10 years of activity.

中文翻译：

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直接成像和相关主题的DNA结构

超疏水性是表面科学领域中众所周知的现象。在这篇综述中，我们报告了一种新颖的方法，该方法利用微制造的超疏水表面来定向和自组织地沉积和悬浮DNA细丝和其他具有生物学意义的大分子。用这种方法获得的自组装结构可通过多种方法用于表征生物化合物，例如电子显微镜，X射线衍射，拉曼光谱和SERS光谱。除了成像之外，所描述的方法还应用于多个领域，例如检测稀释溶液中的少量分子以及创新的模板生长。我们将特别专注于通过透射电子显微镜对DNA分子进行直接成像，并具有将双螺旋的结构细节解析到1.5Å分辨率的能力。回顾首先是关于DNA结构发现的简短历史注释，然后是我们小组在最近十年的活动中获得的结果。