In this article, a tunable pulsed laser induced photoacoustic measurement setup of monitoring glucose concentration was established in the forward mode. In experiments, the time-resolved photoacoustic signal of glucose aqueous solution with different concentrations of 0-300 mg/dl were captured and averaged 512 times, and the photoacoustic peak-to-peak values were recorded using the wavelength scan in NIR region of 1300-2300 nm. The optimal characteristic wavelengths of glucose were determined via the difference spectral and the first derivative spectral algorithm, and correction models between peak-to-peak values of optimal wavelengths and concentration gradients were established using multivariate linear regression algorithm. Experimental results demonstrated that the profile and logarithm shape of time-resolved photoacoustic signal for glucose solutions were in good agreement with photoacoustic theories. The prediction effect of optimal wavelength of 1510 nm was best, its root-mean-square errors of correction and prediction were 12.14 and 8.45 mg/dl, respectively, the correlation coefficient reached 0.9856.

在本文中，在正向模式下建立了可监视的葡萄糖浓度的可调脉冲激光诱导光声测量装置。在实验中，捕获浓度为0-300 mg / dl的葡萄糖水溶液的时间分辨光声信号，并平均512次，并使用波长扫描在1300的NIR区域记录光声峰-峰值。 -2300 nm。通过差光谱和一阶导数光谱算法确定了葡萄糖的最佳特征波长，并使用多元线性回归算法建立了最佳波长的峰峰值与浓度梯度之间的校正模型。实验结果表明，葡萄糖溶液中时间分辨光声信号的轮廓和对数形状与光声理论吻合良好。最佳波长为1510 nm的预测效果最佳，校正和预测的均方根误差分别为12.14和8.45 mg / dl，相关系数达到0.9856。