This article summarizes the fundamental contribution of Francois Jacob in the field of molecular biology. Jacob was one of the handful of scientists who initiated the revolution in biology that took place in the second half of the 20th century. In their landmark publication of 1961, entitled "Genetic Regulatory Mechanisms in the Synthesis of Proteins", François Jacob and Jacques Monod presented a model for the regulation of gene expression deduced from genetic and biochemical studies. They proposed that a new class of genes, regulatory genes, would code for repressors that bind to operator sequences upstream of operons. The impact of the operon model was great: gene expression varies constantly and is under the direct control of proteins, two ideas that were revolutionary at the time they were proposed. It was also rapidly shown that in most organisms, except bacteria, co-regulated genes are not usually grouped together on the genome.

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弗朗索瓦·雅各布（FrançoisJacob），溶血学和Operon模型的发展

本文总结了弗朗索瓦·雅各布在分子生物学领域的基本贡献。雅各布是为数不多的发起20世纪下半叶生物学革命的科学家之一。弗朗索瓦·雅各布（FrançoisJacob）和雅克·莫诺（Jacques Monod）在1961年发表的具有里程碑意义的出版物《蛋白质合成中的基因调控机制》中提出了一种基因和基因化学表达调控模型。他们提出，一类新的基因，即调节基因，将编码与操纵子上游操纵子序列结合的阻遏物。操纵子模型的影响是巨大的：基因表达不断变化，并受蛋白质的直接控制，这是两个提出时具有革命性意义的想法。