Depression is one of the most common psychiatric disorders in people living with HIV (PLHIV). Depression has a negative impact on both mental and physical health and is mainly associated with suboptimal HIV treatment outcomes. To encourage successful aging and the achievement of the 3 × 90 objectives in older PLHIV, the psychological domain must not be neglected. In this context and as data are scarce in West Africa, this study aimed to evaluate the prevalence and the factors associated with severe depressive symptoms in older PLHIV living in this region of the world. Data from PLHIV aged ≥50 years and on ART since ≥6 months were collected in three clinics (two in Côte d’Ivoire, one in Senegal) participating in the West Africa International epidemiological Databases to Evaluate AIDS (IeDEA) collaboration. The severity of depressive symptoms was measured using the Center for Epidemiological Studies Depression scale (CES-D), and associated factors were identified using logistic regressions. The median age of the 334 PLHIV included in the study was 56.7 (53.5–61.1), 57.8% were female, and 87.1% had an undetectable viral load. The prevalence of severe depressive symptoms was 17.9% [95% Confidence Interval (95% CI): 13.8–22.0]. PLHIV with severe depressive symptoms were more likely to be unemployed (adjusted Odd Ratio (aOR) = 2.8; 95% CI: 1.4–5.7), and to be current or former tobacco smokers (aOR = 2.6; 95% CI: 1.3–5.4) but were less likely to be overweight or obese (aOR = 0.4; 95% CI: 0.2–0.8). The prevalence of severe depressive symptoms is high among older PLHIV living in West Africa. Unemployed PLHIV and tobacco smokers should be seen as vulnerable and in need of additional support. Further studies are needed to describe in more details the reality of the aging experience for PLHIV living in SSA. The integration of screening and management of depression in the standard of care of PLHIV is crucial.

中文翻译：

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西非 HIV 感染者的患病率和与严重抑郁症状相关的因素。

抑郁症是 HIV 感染者 (PLHIV) 中最常见的精神障碍之一。抑郁症对心理和身体健康都有负面影响，主要与次优的 HIV 治疗结果有关。为了鼓励老年 PLHIV 成功老龄化和实现 3 × 90 目标，不能忽视心理领域。在这种情况下，由于西非的数据稀少，本研究旨在评估生活在世界该地区的老年 PLHIV 的患病率和与严重抑郁症状相关的因素。在参与西非国际艾滋病评估流行病学数据库 (IeDEA) 合作的三个诊所（两个在科特迪瓦，一个在塞内加尔）收集了年龄≥50 岁和 ART ≥6 个月的 PLHIV 数据。使用流行病学研究中心抑郁量表 (CES-D) 测量抑郁症状的严重程度，并使用逻辑回归确定相关因素。研究中包括的 334 名 PLHIV 的中位年龄为 56.7 (53.5-61.1)，57.8% 为女性，87.1% 的病毒载量无法检测到。严重抑郁症状的患病率为 17.9% [95% 置信区间 (95% CI)：13.8-22.0]。有严重抑郁症状的 PLHIV 更有可能失业（调整后的奇数比 (aOR) = 2.8；95% CI：1.4–5.7），并且现在或以前吸烟者更可能失业（aOR = 2.6；95% CI：1.3–5.4 )，但不太可能超重或肥胖（aOR = 0.4；95% CI：0.2–0.8）。在生活在西非的老年艾滋病毒感染者中，严重抑郁症状的患病率很高。失业的艾滋病病毒感染者和吸烟者应该被视为弱势群体，需要额外的支持。需要进一步的研究来更详细地描述生活在 SSA 的 PLHIV 的老龄化经历的现实。将抑郁症的筛查和管理整合到 PLHIV 的护理标准中是至关重要的。