The chain-growth polymerization mechanism is essentially unsuitable for sequence control due to the statistical propagation feature. However, the development of reversible-deactivation radical polymerization (RDRP) has opened the door to sequence control for carbon–carbon bond-based synthetic polymers carrying various pendant groups on their repeating units. Our group has developed some methodologies and concepts for the synthesis of sequence-controlled oligomers/polymers via radical polymerization. It is crucial to introduce some additional components into the initiator and/or the monomer for RDRP, and in most cases, these components are designed to be removed or transformable afterward. This review focuses on the methodologies we have recently developed for sequence regulation via radical polymerization processes and the sequence-oriented properties of the resultant sequence-controlled polymers. The chain-growth polymerization mechanism is essentially unsuitable for sequence control due to its statistical propagation feature. However, the development of reversible-deactivation radical polymerization has opened the door to the sequence control. Our group has developed some methodologies and concepts for the synthesis of sequence-controlled oligomers/polymers via radical polymerization: it is crucial to introduce some additional components into the initiator and/or the monomer for reversible-deactivation radical polymerization and in most cases these components are designed to be removed or transformable afterward.

中文翻译：

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通过自由基聚合产生的序列控制的低聚物/聚合物的构建方法和序列导向特性

由于统计传播特性，链增长聚合机制本质上不适合序列控制。然而，可逆失活自由基聚合（RDRP）的发展为基于碳-碳键的合成聚合物在其重复单元上携带各种侧基的序列控制打开了大门。我们的小组已经开发了一些通过自由基聚合合成序列控制的低聚物/聚合物的方法和概念。在 RDRP 的引发剂和/或单体中引入一些额外的组分是至关重要的，并且在大多数情况下，这些组分被设计为随后被去除或可转化。本综述重点关注我们最近开发的通过自由基聚合过程进行序列调节的方法，以及由此产生的序列控制聚合物的序列导向特性。由于其统计传播特性，链增长聚合机制本质上不适合序列控制。然而，可逆失活自由基聚合的发展为序列控制打开了大门。我们的团队开发了一些通过自由基聚合合成序列控制的低聚物/聚合物的方法和概念：将一些额外的成分引入引发剂和/或单体中是至关重要的，用于可逆失活自由基聚合，在大多数情况下这些成分设计为以后可移除或可变形。