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Human hazard potential of nanocellulose: quantitative insights from the literature.
Nanotoxicology ( IF 5 ) Pub Date : 2020-09-10 , DOI: 10.1080/17435390.2020.1814440
Natasha Stoudmann 1 , Mélanie Schmutz 1 , Cordula Hirsch 2 , Bernd Nowack 1 , Claudia Som 1
Affiliation  

Abstract

This review aims to elucidate the current knowledge and future research needs regarding the hazard potential of nanocellulose to human health. Growing interest from research and industry alike has led to increasing likelihood of human contact to the material via various exposure routes. Although a number of comprehensive reviews on human health hazards of nanocellulose have been conducted, this paper brings new insights as it systematically analyzes and quantitatively assesses the results of in vivo and in vitro tests in terms of investigated endpoints, tested concentration ranges, physicochemical properties, surface modifications and source of the tested nanocellulose, exposure route, and cell lines used. The quality of the studies is further inspected based on various established criteria. Considering the rapid development of nanocellulose-based products and the novelty of the material, human health studies remain scarce. By assessing those that have been conducted, patterns and gaps were identified that will be helpful to guide future research. The results show that there are still significant uncertainties remaining, particularly regarding in vivo testing, with pulmonary exposure showing some cause for concern. Although a substantial number of in vitro studies have been undertaken, results are often conflicting. The detected effects could not be directly attributed to size of nanoparticles, cell lines, surface modifications or tested concentrations. This may also be linked to the varying quality of the studies. This review ends by identifying key gaps to help pave the way for future research and ensure the safe development and use of nanocellulose.



中文翻译:

纳米纤维素对人类的潜在危害:来自文献的定量见解。

摘要

这篇综述旨在阐明有关纳米纤维素对人体健康的潜在危害的当前知识和未来研究需求。研究和行业的兴趣日益增长,导致人们通过各种暴露途径接触材料的可能性增加。尽管已对纳米纤维素对人类健康的危害进行了许多全面的综述,但本文对系统分析和定量评估体内体外的结果提出了新的见解根据研究的终点,测试的浓度范围,理化性质,表面修饰和测试的纳米纤维素的来源,暴露途径和所用细胞系进行测试。研究质量将根据各种既定标准进行进一步检查。考虑到基于纳米纤维素的产品的快速发展和材料的新颖性,人类健康研究仍然很少。通过评估已进行的研究,确定了模式和差距,这将有助于指导未来的研究。结果表明,仍然存在明显的不确定性,尤其是在体内测试方面,肺部暴露显示出一些令人担忧的原因。虽然大量体外已经进行了研究,结果常常是矛盾的。检测到的效果不能直接归因于纳米颗粒的大小,细胞系,表面修饰或测试浓度。这也可能与研究质量的变化有关。这篇综述以确定主要差距为结尾,以帮助为将来的研究铺平道路,并确保安全开发和使用纳米纤维素。

更新日期:2020-09-10
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