Preparation of both 125 I-labeled insulin and insulin-like growth factor 1 (IGF-1) was critical because it enabled a detailed characterization of binding properties of these important hormones towards their cognate transmembrane receptors. Binding modes of hundreds of hormone derivatives were analyzed using competition radioligand binding assays. This effort has resulted in development of six insulin analogs that are today clinically used for the treatment of diabetes. Here we will briefly summarize a history of insulin research employing iodinated hormones.

中文翻译：

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胰岛素研究中的放射性标记激素，小评论

制备 125 I 标记的胰岛素和胰岛素样生长因子 1 (IGF-1) 至关重要，因为它能够详细表征这些重要激素与其同源跨膜受体的结合特性。使用竞争性放射性配体结合测定法分析了数百种激素衍生物的结合模式。这一努力导致开发了六种胰岛素类似物，目前已在临床上用于治疗糖尿病。在这里，我们将简要总结使用碘化激素进行胰岛素研究的历史。