Nanozymes with intrinsic enzyme‐like properties have attracted significant interest owing to their capability to address the limitations of traditional enzymes such as fragility, high cost and difficult mass production. However, the currently reported nanozymes are generally less active than natural enzymes. In recent years, with the rapid development of nanoscience and nanotechnology, single‐atom nanozymes (SAzymes) with well‐defined electronic and geometric structures have shown a promise to serve as direct surrogates of traditional enzymes by mimicking the highly evolved catalytic center of natural enzymes. In this review, we will introduce the enzymatic characteristics and recent advances of SAzymes, and summarize their significant applications from in vitro detection to in vivo monitoring and therapy.

中文翻译：

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单原子纳米酶研究的进展†

具有内在类酶特性的纳米酶由于能够解决传统酶的局限性（如脆弱性，高成本和难以批量生产）而备受关注。然而，当前报道的纳米酶通常不如天然酶具有活性。近年来，随着纳米科学和纳米技术的飞速发展，具有定义明确的电子和几何结构的单原子纳米酶（SAzymes）有望通过模仿天然酶高度进化的催化中心，作为传统酶的直接替代物。 。在这篇综述中，我们将介绍SAzymes的酶学特性和最新进展，并总结其从体外检测到体内的重要应用。 监测和治疗。