A simple synthesis of a 2,4‐tethered glucosaminyl donor has been developed. The commonly synthesized 2‐azido‐2‐deoxy glucosyl donor is transferred into the cyclic carbamate using a Staudinger azide reduction followed by CO₂ capture giving an isocyate. This highly reactive intermediate readily participate in an intramolecular ring‐closure with the 4‐OH in a one‐pot fashion. The novel donor type achieved can then be N‐functionalized and used in glycosylation reactions.

中文翻译：

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使用环状氨基甲酸酯的糖基供体的构象锁定

已开发出2,4-束缚的氨基葡萄糖氨基供体的简单合成方法。使用Staudinger叠氮化物还原法将通常合成的2-叠氮基-2-脱氧葡萄糖基供体转移到环状氨基甲酸酯中，然后捕获CO ₂以获得异氰酸酯。这种高反应性中间体很容易以一锅方式与4-OH参与分子内闭环。然后可以将N型官能化的新型供体用于糖基化反应。