Injectable hydrogels with conductivity are highly desirable as scaffolds for the engineering of various electrical stimuli-responsive tissues, including nerve, muscle, retina, and bone. However, oxygen deprivation within scaffolds can lead to failure by causing cell necrosis. Therefore, an oxygen release conductive injectable hydrogel can serve as a promising support for the regeneration of such tissues. In the present study, H₂O₂-loaded polylactic acid microparticles were fabricated. Then, gelatin-graft-polypyrrole with various pyrrole contents and periodate-oxidized pectin were synthesized, and consequently, injectable conductive hydrogel/microparticle scaffolds, inside which catalase was grafted and trapped, were obtained. The results revealed that spherical particles with a mean diameter of 60.39 μm and encapsulation efficiency of 49.64 %, which persistently provided oxygen up to 14 days, were achieved. Investigations on hydrogels revealed that with the increase of pyrrole content of gelatin-graft-polypyrrole from 0 to 15 %, the swelling ratio, pore size, porosity, and conductivity were increased from 6.5 to 11.8, 173.13 μm–295.96 μm, 79.7%–93.8%, and from 0.06 mS/m to 2.14 mS/m, respectively. On the other hand, the crosslinking degree and compressive modulus of hydrogels were shown to decrease from 67.24%–27.35%, and from 214.1 kPa to 64.4 kPa, respectively. Moreover, all formulations supported cell viability and attachment. Overall, the hydrogel/particle scaffold with the merits of electrical conductivity, injectability, compatibility, and sustained oxygen release can be used as a tissue engineering scaffold, promoting the regeneration of electricity responsive tissues. Considering all the aforementioned characteristics and behavior of the fabricated scaffolds, they may be promising candidates for bone tissue engineering applications.

具有导电性的可注射水凝胶作为用于各种电刺激响应组织（包括神经，肌肉，视网膜和骨骼）工程化的支架是非常需要的。但是，支架内的缺氧会导致细胞坏死，从而导致衰竭。因此，释放氧的导电性可注射水凝胶可以用作此类组织再生的有前途的支持。在本研究中，H ₂ O ₂制备了载有负载的聚乳酸微粒。然后，合成具有各种吡咯含量的明胶接枝的聚吡咯和高碘酸盐氧化的果胶，因此，获得了可注射的导电水凝胶/微粒支架，其内部接枝并捕获了过氧化氢酶。结果显示，获得了平均直径为60.39μm和包封效率为49.64％的球形颗粒，该球形颗粒持续提供长达14天的氧气。对水凝胶的研究表明，随着明胶接枝聚吡咯的吡咯含量从0增加到15％，溶胀率，孔径，孔隙率和电导率从6.5增加到11.8，从173.13 μm–295.96μm，79.7％–分别为93.8％和0.06 mS / m至2.14 mS / m。另一方面，结果表明，水凝胶的交联度和压缩模量分别从67.24％–27.35％和214.1 kPa降至64.4 kPa。此外，所有制剂均支持细胞活力和附着。总的来说，具有导电性，可注射性，相容性和持续释放氧的优点的水凝胶/颗粒支架可用作组织工程支架，促进电响应性组织的再生。考虑到制造支架的所有上述特征和行为，它们可能是骨组织工程应用的有前途的候选者。具有导电性，可注射性，相容性和持续释放氧的优点的水凝胶/颗粒支架可用作组织工程支架，促进电响应性组织的再生。考虑到制造支架的所有上述特征和行为，它们可能是骨组织工程应用的有前途的候选者。具有导电性，可注射性，相容性和持续释放氧的优点的水凝胶/颗粒支架可用作组织工程支架，促进电响应性组织的再生。考虑到制造支架的所有上述特征和行为，它们可能是骨组织工程应用的有前途的候选者。