Malignant gliomas are central nervous system tumors and remain among the most treatment-resistant cancers. Exome sequencing has revealed significant heterogeneity and important insights into the molecular pathogenesis of gliomas. Mutations in chromatin modifiers—proteins that shape the epigenomic landscape through remodeling and regulation of post-translational modifications on chromatin—are very frequent and often define specific glioma subtypes. This suggests that epigenomic reprogramming may be a fundamental driver of glioma. Here, we describe the key chromatin regulatory pathways disrupted in gliomas, delineating their physiological function and our current understanding of how their dysregulation may contribute to gliomagenesis.

恶性胶质瘤是中枢神经系统肿瘤，仍然是最难治疗的癌症之一。外显子组测序揭示了对胶质瘤分子发病机制的显着异质性和重要见解。染色质修饰剂（通过重塑和调节染色质上的翻译后修饰来塑造表观基因组景观的蛋白质）中的突变非常频繁，并且通常定义特定的神经胶质瘤亚型。这表明表观基因组重编程可能是胶质瘤的基本驱动因素。在这里，我们描述了神经胶质瘤中被破坏的关键染色质调节途径，描绘了它们的生理功能以及我们目前对它们的失调如何促进神经胶质瘤形成的理解。