The cell composition of leukocyte infiltrates in the endometrium, myometrium, and vaginal walls was studied in Wistar rats with modeled chronic endomyometritis after administration of IFNγ (0.1 μg/100 g body weight) in different daily regimens (10.00 or 20.00). Morning injections of this cytokine ameliorated inflammatory infiltration of the uterine wall and vagina, but increased the content of neutrophils in the endometrium. Evening cytokine injections reduced neutrophilic infiltration, enhanced mononuclear infiltration, and had no effect on plasmacytic infiltration of the uterine and vaginal walls. In the vaginal wall, both IFNγ administration schedules decreased neutrophil content. The data indicate the necessity to take into account the circadian rhythms in IFN therapy.

中文翻译：

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在一天中不同时间用干扰素-γ 治疗实验性子宫内膜炎大鼠子宫和阴道组织中白细胞浸润成分的比较评估

在以不同的每日方案（10.00 或 20.00）施用 IFNγ（0.1 μg/100 g 体重）后，在患有模型化慢性子宫内膜炎的 Wistar 大鼠中研究了子宫内膜、子宫肌层和阴道壁中白细胞浸润的细胞组成。早晨注射这种细胞因子改善了子宫壁和阴道的炎症浸润，但增加了子宫内膜中中性粒细胞的含量。晚间细胞因子注射减少了中性粒细胞浸润，增强了单核细胞浸润，并且对子宫和阴道壁的浆细胞浸润没有影响。在阴道壁中，两种 IFNγ 给药方案都降低了中性粒细胞含量。数据表明在 IFN 治疗中必须考虑昼夜节律。