Warnerin pretreatment of catheter segments subcutaneously implanted to mice under conditions of immunosuppression led to a significant increase in the number of neutrophils in the surrounding tissues on day 1; the number of fibroblasts tended to decrease by day 3. Immunohistochemical study showed the presence of T and B lymphocytes on day 3, but no positive reactions to vimentin and CD34 were observed during the first 2 days. These changes suggest that warnerin reduced the intensity of regeneration processes in tissues around the implant, which can be used for suppression of fibrosis.

中文翻译：

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免疫抑制条件下阳离子肽华纳林对小鼠植入聚四氟乙烯导管周围结缔组织再生作用的形态学特征

Warnerin 在免疫抑制条件下对小鼠皮下植入的导管段进行预处理，导致第 1 天周围组织中的中性粒细胞数量显着增加；成纤维细胞的数量在第 3 天趋于减少。免疫组织化学研究显示第 3 天存在 T 和 B 淋巴细胞，但在前 2 天未观察到波形蛋白和 CD34 的阳性反应。这些变化表明，华纳林降低了植入物周围组织的再生过程强度，可用于抑制纤维化。