This review is dedicated to the memory of Dr. Sergei L’vovich Grokhovsky, who was a distinguished scientists and experimenter; it briefly describes one aspect of his multifaceted research activity. Gro-khovsky was the first to describe the specificity of ultrasound-induced cleavage of internucleotide bonds in double-stranded B-DNA. The discovery of this new physicochemical phenomenon made it possible to associate the cleavage effects with conformational and dynamic features of B-DNA nucleotide sequences and provided a new basis for bioinformatics genome analyses. Certain conformational dynamic specifics are characteristic of functional DNA regions; this makes it possible to formulate and solve a number of problems of epigenetics and carcinogenesis.

中文翻译：

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超声DNA切割：调节基因组区域的构象动态特征和测序错误的分析。

这篇评论是为了纪念谢尔盖·L'vovich Grokhovsky博士，他是一位杰出的科学家和实验者。它简要描述了他多方面的研究活动的一个方面。Gro-khovsky率先描述了超声诱导双链B-DNA中核苷酸间键断裂的特异性。这一新的物理化学现象的发现使得将裂解作用与B-DNA核苷酸序列的构象和动态特征联系起来成为可能，并为生物信息学基因组分析提供了新的基础。某些构象动态细节是功能性DNA区域的特征；这使制定和解决表观遗传学和致癌性的许多问题成为可能。