Penicillin allergy is frequently reported in adults and children. Recent studies suggest that microbiota plays a key role in the development and progression of allergy. In this study, the relationship between vaginal microbiome and pregnant women with penicillin allergy was investigated. Vaginal samples before labor from 12 pregnant women with penicillin allergy and 15 non-allergic pregnant women were collected. Bacterial community structure of all study subjects and the discrepancies between the two groups were analyzed using 16S rRNA sequencing based on Illumina Hiseq 2500 platform. The abundant phyla among all participants were Firmicutes, Actinobacteria and Bacteroidetes. The predominant genus was Lactobacillus. Compared to non-allergic pregnant women, Actinobacteria, Coriobacteriaceae, Lachnospiraceae, Paraprevotella and Anoxybacillus significantly decreased, whereas Deltaproteobacteria, Peptostreptococcaceae, Enterococcus and Megamonas were more abundant in penicillin allergic women. Additionally, obvious discrepancies were observed in the co-abundance network at the genus level between the two groups. There were differences in the microbial community structure and composition of reproduction tract between penicillin allergic and non-allergic pregnant women. These shifts may be related to maternal and neonatal health.

中文翻译：

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青霉素过敏孕妇阴道微生物组和相对共丰度网络的改变。

成人和儿童经常报告青霉素过敏。最近的研究表明，微生物群在过敏症的发展和进展中起着关键作用。在这项研究中，调查了阴道微生物群与青霉素过敏孕妇之间的关系。收集了12名青霉素过敏孕妇和15名非过敏孕妇的产前阴道样本。使用基于Illumina Hiseq 2500平台的16S rRNA测序分析所有研究对象的细菌群落结构和两组之间的差异。所有参与者中丰富的门是厚壁菌门、放线菌门和拟杆菌门。主要的属是乳酸杆菌。与非过敏性孕妇相比，放线菌科、球菌科、毛螺菌科、Paraprevotella 和 Anoxybacillus 显着减少，而 Deltaproteobacteria、Peptostreptococcaceae、Enterococcus 和 Megamonas 在青霉素过敏的女性中更丰富。此外，在两组之间在属水平的共丰度网络中观察到明显的差异。青霉素过敏和非过敏孕妇的生殖道微生物群落结构和组成存在差异。这些转变可能与孕产妇和新生儿健康有关。青霉素过敏和非过敏孕妇的生殖道微生物群落结构和组成存在差异。这些转变可能与孕产妇和新生儿健康有关。青霉素过敏和非过敏孕妇的生殖道微生物群落结构和组成存在差异。这些转变可能与孕产妇和新生儿健康有关。