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WE43 and WE43-T5 Mg alloys screws tested in-vitro cellular adhesion and differentiation assay and in-vivo histomorphologic analysis in an ovine model.
Journal of Biomaterials Applications ( IF 2.9 ) Pub Date : 2020-09-09 , DOI: 10.1177/0885328220956788
Andrea Torroni 1 , Lukasz Witek 2 , Hayat Pelin Fahliogullari 1 , Joao Paulo Bortoli 1 , Amel Ibrahim 1 , Jacques Hacquebord 1 , Nikhil Gupta 3 , Paulo Coelho 1
Affiliation  

WE43 Mg alloy proved to be an ideal candidate for production of resorbable implants in both clinical and trial settings. In previous studies we tested biocompatibility and degradation properties of WE43 (as-cast) and artificially aged (WE43-T5) Mg alloys in a sheep model. Both alloys showed excellent biocompatibility with the as-cast, WE43, form showing increased degradability compared to the artificially aged, WE43-T5. In the present study, our group assessed the biological behavior and degradation pattern of the same alloys when implanted as endosteal implants in a sheep model. Twelve screws (3x15 mm) were evaluated, one screw per each composition was placed bi-cortically in the mandible of each animal with a titanium (2x12 mm) screw serving as an internal positive control. At 6 and 24 weeks histomorphological analysis was performed, at 6 weeks as cast, WE43, yielded a higher degradation rate, increased bone remodeling and osteolysis compared to the WE43-T5 alloy; however, at 24 weeks WE43-T5 showed higher degradation rate and increased bone remodeling than as-cast. In vitro assay of cell growth, adhesion and differentiation was also conducted to investigate possible mechanisms underlying the behavior expressed from the alloys in vivo. In conclusion WE43-T5 indicated bone/implant interaction properties that makes it more suitable for fabrication of endosteal bone screws.



中文翻译:

WE43 和 WE43-T5 镁合金螺钉在绵羊模型中测试了体外细胞粘附和分化测定以及体内组织形态学分析。

WE43 镁合金被证明是在临床和试验环境中生产可吸收植入物的理想候选者。在之前的研究中,我们在绵羊模型中测试了 WE43(铸态)和人工时效 (WE43-T5) 镁合金的生物相容性和降解性能。两种合金都表现出与铸态 WE43 的优异生物相容性,与人工时效 WE43-T5 相比,表现出更高的可降解性。在本研究中,我们小组评估了相同合金在羊模型中作为骨内植入物植入时的生物学行为和降解模式。评估了 12 个螺钉 (3x15 mm),每个组合物一个螺钉被双皮质地放置在每只动物的下颌骨中,钛 (2x12 mm) 螺钉用作内部阳性对照。在 6 周和 24 周进行组织形态学分析,与 WE43-T5 合金相比,在铸造 6 周时,WE43 产生了更高的降解率、增加的骨重塑和骨溶解;然而,在 24 周时,WE43-T5 显示出比铸态更高的降解率和增加的骨重塑。还进行了细胞生长、粘附和分化的体外测定,以研究合金在体内表达的行为的可能机制。总之,WE43-T5 表明了骨/植入物的相互作用特性,使其更适合制造骨内接骨螺钉。

更新日期:2020-09-10
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