Mesenchymal stem cells (MSCs) present in multiple tissues can self-renew and differentiate into multiple lineages including the bone, cartilage, muscle, cardiac tissue, and connective tissue. Key events, including cell proliferation, lineage commitment, and MSC differentiation, are ensured by precise gene expression regulation. ATP-dependent chromatin alteration is one form of epigenetic modifications that can regulate the transcriptional level of specific genes by utilizing the energy from ATP hydrolysis to reorganize chromatin structure. ATP-dependent chromatin remodeling complexes consist of a variety of subunits that together perform multiple functions in self-renewal and lineage specification. This review highlights the important role of ATP-dependent chromatin remodeling complexes and their different subunits in modulating MSC fate determination and discusses the proposed mechanisms by which ATP-dependent chromatin remodelers function.

中文翻译：

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间充质干细胞谱系规范中的ATP依赖性染色质重塑复合物。

存在于多种组织中的间充质干细胞（MSC）可以自我更新并分化为多种谱系，包括骨骼，软骨，肌肉，心脏组织和结缔组织。精确的基因表达调控可确保关键事件，包括细胞增殖，谱系定型和MSC分化。ATP依赖的染色质改变是表观遗传修饰的一种形式，可以利用ATP水解产生的能量重组染色质结构，从而调节特定基因的转录水平。ATP依赖的染色质重塑复合物由多种亚单位组成，这些亚单位在自我更新和血统规范中共同执行多种功能。