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Combined Transplantation of Mesenchymal Stem Cells and Endothelial Colony-Forming Cells Accelerates Refractory Diabetic Foot Ulcer Healing
Stem Cells International ( IF 4.3 ) Pub Date : 2020-09-09 , DOI: 10.1155/2020/8863649
Liling Zhao 1 , Zi Guo 1 , Ke Chen 1 , Wenjun Yang 1 , Xinxing Wan 1 , Pingyu Zeng 2 , Honghui He 1 , Yufang Luo 1 , Qian Xiao 1 , Zhaohui Mo 1
Affiliation  

Background. This study is aimed at investigating the effect of combined transplantation of umbilical cord mesenchymal stem cells (UCMSCs) and umbilical cord blood-derived endothelial colony-forming cells (ECFCs) on diabetic foot ulcer healing and at providing a novel therapy for chronic diabetic foot ulcer. Methods. We reported the treatment of refractory diabetic foot ulcers in twelve patients. Among them, five patients had two or more wounds; thus, one wound in the same patient was treated with cell injection, and other wounds were regarded as self-controls. The remaining seven patients had only one wound; therefore, the difference between the area of wound before and after treatment was estimated. The UCMSCs and ECFCs were injected into the wound along with topically applied hyaluronic acid (HA). Results. In this report, we compared the healing rate of multiple separate wounds in the same foot of the same patient: one treated with cell injection combined with topically applied HA-based hydrogel and was later covered by the hydrocolloid dressings, while the self-control wounds were only treated with conventional therapy and covered by the hydrocolloid dressings. The wound underwent cell injection showed accelerated healing in comparison to control wound within the first week after treatment. In other diabetic patients with only one refractory wound, the healing rate after cell transplantation was significantly faster than that before injection. Two large wounds healed without needing skin grafts after combination therapy of cell injection and HA. After four weeks of combination treatment, wound closure was reached in six patients, and the wounds of the other six patients were significantly reduced in size. Conclusions. Our study suggests that the combination of UCMSCs, ECFCs, and HA can safely synergize the accelerated healing of refractory diabetic foot ulcers.

中文翻译:

间充质干细胞和内皮集落形成细胞联合移植加速难治性糖尿病足溃疡愈合

背景。本研究旨在探讨脐带间充质干细胞(UCMSCs)和脐带血源性内皮集落形成细胞(ECFCs)联合移植对糖尿病足溃疡愈合的影响,为慢性糖尿病足溃疡提供新的治疗方法。 . 方法. 我们报告了 12 名患者难治性糖尿病足溃疡的治疗。其中,5例患者有2处以上伤口;因此,对同一患者的一处伤口进行了细胞注射治疗,其他伤口视为自我对照。其余七名患者只有一处伤口;因此,估计了治疗前后伤口面积的差异。UCMSCs 和 ECFCs 与局部应用的透明质酸 (HA) 一起被注射到伤口中。结果. 在本报告中,我们比较了同一患者同一足部多处不同伤口的愈合率:一个采用细胞注射联合局部应用 HA 基水凝胶进行治疗,后来被水胶体敷料覆盖,而自我控制的伤口仅用常规疗法治疗并由水胶体敷料覆盖。与治疗后第一周内的对照伤口相比,接受细胞注射的伤口愈合速度加快。在其他只有一处难治性伤口的糖尿病患者中,细胞移植后的愈合速度明显快于注射前。细胞注射和HA联合治疗后,两个大伤口无需植皮即可愈合。经过 4 周的联合治疗,6 名患者的伤口愈合,结论。我们的研究表明,UCMSCs、ECFCs 和 HA 的组合可以安全地协同加速难治性糖尿病足溃疡的愈合。
更新日期:2020-09-10
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