Huntington’s disease (HD) is a hereditary autosomal dominant neurodegenerative disease. Although studies have shown that blood oxidative stress markers are dysregulated in HD patients, clinical data on the blood oxidative stress markers of HD patients is inconsistent. To better understand the pathogenesis of HD, we performed a systematic review and meta-analysis of blood oxidative stress markers in HD patients and healthy control (HC) subjects. A database search from PubMed and Web of Science identified 12 studies with 375 HD patients and 447 HC subjects in this meta-analysis. A random-effects meta-analysis showed that blood lipid peroxidation products (Hedges’ , , ), 8-hydroxyguanosine (Hedges’ , , ) levels, and the activity of glutathione peroxidase (Hedges’ , , ) were significantly increased in HD patients compared to controls. In contrast, reduced glutathione levels were lower in HD patients than in controls (Hedges’ , , ). However, blood superoxide dismutase, cholesterol, high-density lipoproteins, low-density lipoproteins, and triglycerides did not show significant differences between cases and controls. Taken together, this study clarified the associations between blood oxidative stress markers and HD, supporting the clinical evidence that HD is accompanied by increased oxidative stress.

中文翻译：

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亨廷顿氏病患者的血液氧化应激标记异常：一项荟萃分析研究。

亨廷顿舞蹈病（HD）是遗传性常染色体显性遗传神经退行性疾病。尽管研究表明，HD患者的血液氧化应激标志物异常，但有关HD患者血液氧化应激标志物的临床数据却不一致。为了更好地了解HD的发病机制，我们对HD患者和健康对照（HC）受试者的血液氧化应激标记物进行了系统的综述和荟萃分析。来自PubMed和Web of Science的数据库搜索在这项荟萃分析中确定了12项针对375名HD患者和447 HC受试者的研究。荟萃分析显示，血脂过氧化产物（Hedges'， ， ）， 8-羟基鸟苷（Hedges'， ， ）水平以及谷胱甘肽过氧化物酶（Hedges'， ， 与对照组相比，HD患者的）显着增加。相比之下，HD患者降低的谷胱甘肽水平低于对照组（Hedges's， ， ）。但是，血液超氧化物歧化酶，胆固醇，高密度脂蛋白，低密度脂蛋白和甘油三酸酯在病例和对照组之间没有显示出显着差异。两者合计，这项研究阐明了血液氧化应激标记物与HD之间的关联，支持了HD伴随着氧化应激增加的临床证据。