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Interactions between Gut Microbiota and Immunomodulatory Cells in Rheumatoid Arthritis.
Mediators of Inflammation ( IF 4.6 ) Pub Date : 2020-09-09 , DOI: 10.1155/2020/1430605
Huihui Xu 1 , Hongyan Zhao 1 , Danping Fan 2, 3 , Meijie Liu 1 , Jinfeng Cao 1 , Ya Xia 2, 4 , Dahong Ju 1 , Cheng Xiao 2, 3, 5 , Qingdong Guan 6, 7, 8
Affiliation  

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases caused by abnormal immune activation and immune tolerance. Immunomodulatory cells (ICs) play a critical role in the maintenance and homeostasis of normal immune function and in the pathogenesis of RA. The human gastrointestinal tract is inhabited by trillions of commensal microbiota on the mucosal surface that play a fundamental role in the induction, maintenance, and function of the host immune system. Gut microbiota dysbiosis can impact both the local and systemic immune systems and further contribute to various diseases, such as RA. The neighbouring intestinal ICs located in distinct intestinal mucosa may be the most likely intermediary by which the gut microbiota can affect the occurrence and development of RA. However, the reciprocal interaction between the components of the gut microbiota and their microbial metabolites with distinct ICs and how this interaction may impact the development of RA are not well studied. Therefore, a better understanding of the gut microbiota, ICs, and their interactions might improve our knowledge of the mechanisms by which the gut microbiota contribute to RA and facilitate the further development of novel therapeutic approaches. In this review, we have summarized the roles of the gut microbiota in the immunopathogenesis of RA, especially the interactions between the gut microbiota and ICs, and further discussed the strategies for treating RA by targeting/regulating the gut microbiota.

中文翻译:

类风湿性关节炎中肠道微生物群与免疫调节细胞之间的相互作用。

类风湿性关节炎(RA)是由异常的免疫激活和免疫耐受引起的最常见的自身免疫性疾病之一。免疫调节细胞 (IC) 在正常免疫功能的维持和稳态以及 RA 的发病机制中起着关键作用。人类胃肠道的黏膜表面存在数以万亿计的共生微生物群,它们在宿主免疫系统的诱导、维持和功能方面发挥着重要作用。肠道菌群失调会影响局部和全身免疫系统,并进一步导致各种疾病,例如 RA。位于不同肠黏膜的相邻肠道 ICs 可能是肠道菌群影响 RA 发生发展的最可能中介。然而,肠道微生物群的组成部分与其具有不同 IC 的微生物代谢物之间的相互作用以及这种相互作用如何影响 RA 的发展还没有得到很好的研究。因此,更好地了解肠道微生物群、IC 及其相互作用可能会提高我们对肠道微生物群促成 RA 的机制的了解,并促进新治疗方法的进一步发展。在这篇综述中,我们总结了肠道微生物群在 RA 免疫发病机制中的作用,特别是肠道微生物群与 IC 之间的相互作用,并进一步讨论了通过靶向/调节肠道微生物群来治疗 RA 的策略。因此,更好地了解肠道微生物群、IC 及其相互作用可能会提高我们对肠道微生物群促成 RA 的机制的了解,并促进新治疗方法的进一步发展。在这篇综述中,我们总结了肠道微生物群在 RA 免疫发病机制中的作用,特别是肠道微生物群与 IC 之间的相互作用,并进一步讨论了通过靶向/调节肠道微生物群来治疗 RA 的策略。因此,更好地了解肠道微生物群、IC 及其相互作用可能会提高我们对肠道微生物群促成 RA 的机制的了解,并促进新治疗方法的进一步发展。在这篇综述中,我们总结了肠道微生物群在 RA 免疫发病机制中的作用,特别是肠道微生物群与 IC 之间的相互作用,并进一步讨论了通过靶向/调节肠道微生物群来治疗 RA 的策略。
更新日期:2020-09-10
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