Abstract

Memory dysfunction and associated hippocampal disturbances play crucial roles in cognitive impairment of schizophrenia. To examine the relationships between cognitive function and the hippocampal subfields (HSs) in first-episode never-treated (FENT) schizophrenia patients, the HSs were segmented in 39 FENT patients and 30 healthy controls using a state-of the-art automated algorithm. We found no significant differences in any HSs between the patients and controls. However, multivariate regression analysis showed that the left cornu ammonis 1 (CA1), left hippocampal tail, left presubiculum, and right molecular layer contributed 40% to the variance of the PANSS negative symptom score. After adjusting for sex, age, education, and intracranial volume, the partial correlation analysis showed that the volumes of left CA1, CA3, CA4, molecular layer, granule cell layer and both left and right subiculum were negatively correlated with the MATRICS consensus cognitive battery (MCCB) Hopkins Verbal Learning Test (HVLT). Multiple regression analysis showed that the left CA1 and CA3 hippocampal abnormalities contributed 66% to the variance of the HVLT. Our results suggest no detectable HS deficits were found in FENT schizophrenia patients. However, the HSs may be involved in the symptoms and cognitive deficits of schizophrenia patients in the early phase of their illness.

中文翻译：

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首发和未治疗的精神分裂症患者海马亚区的认知缺陷和临床症状。

摘要

记忆功能障碍和相关的海马障碍在精神分裂症的认知障碍中起着至关重要的作用。为了检查首发未治疗 (FENT) 精神分裂症患者的认知功能与海马亚区 (HS) 之间的关系，使用最先进的自动化算法将 HS 分为 39 名 FENT 患者和 30 名健康对照。我们发现患者和对照组之间的任何 HS 均无显着差异。然而，多元回归分析显示左角1（CA1）、左海马尾、左下颌骨和右分子层对PANSS阴性症状评分的方差贡献了40%。调整性别、年龄、学历、颅内体积后偏相关分析显示左侧CA1、CA3、CA4、分子层、颗粒细胞层和左右下叶与 MATRICS 共识认知电池 (MCCB) 霍普金斯语言学习测试 (HVLT) 呈负相关。多元回归分析显示左侧CA1和CA3海马异常对HVLT的方差贡献了66%。我们的结果表明在 FENT 精神分裂症患者中未发现可检测到的 HS 缺陷。然而，HSs 可能与精神分裂症患者在疾病早期的症状和认知缺陷有关。我们的结果表明在 FENT 精神分裂症患者中未发现可检测到的 HS 缺陷。然而，HSs 可能与精神分裂症患者在疾病早期的症状和认知缺陷有关。我们的结果表明在 FENT 精神分裂症患者中未发现可检测到的 HS 缺陷。然而，HSs 可能与精神分裂症患者在疾病早期的症状和认知缺陷有关。