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The Role of miR-210 in the Biological System: A Current Overview.
Human Heredity ( IF 1.8 ) Pub Date : 2020-09-09 , DOI: 10.1159/000509280
Xu Hui 1 , Hisham Al-Ward 2 , Fahmi Shaher 3 , Chun-Yang Liu 1 , Ning Liu 1
Affiliation  

Background: MicroRNAs (miRNAs) represent a group of non-coding RNAs measuring 19–23 nucleotides in length and are recognized as powerful molecules that regulate gene expression in eukaryotic cells. miRNAs stimulate the post-transcriptional regulation of gene expression via direct or indirect mechanisms. Summary: miR-210 is highly upregulated in cells under hypoxia, thereby revealing its significance to cell endurance. Induction of this mRNA expression is an important feature of the cellular low-oxygen response and the most consistent and vigorous target of HIF. Key Message: miR-210 is involved in many cellular functions under the effect of HIF-1α, including the cell cycle, DNA repair, immunity and inflammation, angiogenesis, metabolism, and macrophage regulation. It also plays an important regulatory role in T-cell differentiation and stimulation.
Hum Hered


中文翻译:

miR-210在生物系统中的作用:最新概述。

背景:微小RNA(miRNA)代表一组长度为19-23个核苷酸的非编码RNA,被公认为是调节真核细胞基因表达的强大分子。miRNA通过直接或间接机制刺激基因表达的转录后调控。摘要:在缺氧条件下,miR-210在细胞中高度上调,从而揭示了其对细胞耐受性的重要性。诱导此mRNA表达是细胞低氧反应的重要特征,也是HIF最一致,最有力的靶标。关键信息:miR-210在HIF-1α的作用下参与许多细胞功能,包括细胞周期,DNA修复,免疫和炎症,血管生成,代谢和巨噬细胞调节。它还在T细胞分化和刺激中起重要的调节作用。
嗡嗡声
更新日期:2020-09-10
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