Abstract Thiophenes are a highly important group of heterocycles and have been of great interest to researchers due to their various reactivities. Many synthetic strategies are used to generate functionalized thiophene derivatives. Several reactions are described, depending on the reactivity of the substituents attached to the thiophene nucleus toward different nucleophiles to yield the versatile thiophene products. Many diverse applications have been utilized for thiophenes from medicinal chemistry to material science. Graphical Abstract

中文翻译：

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多功能噻吩合成子的合成策略和功能反应性

摘要 噻吩是一类非常重要的杂环化合物，由于其多种反应活性而引起了研究人员的极大兴趣。许多合成策略用于生成功能化噻吩衍生物。描述了几种反应，这取决于连接到噻吩核的取代基对不同亲核试剂的反应性，以产生多功能的噻吩产品。从药物化学到材料科学，噻吩有许多不同的应用。图形概要