ABSTRACT

Introduction

The utilization of polymeric nanoparticles, as drug payloads, has been extensively prevailed in cancer therapy. However, the precise distribution of these nanocarriers is restrained by various physiological and cellular obstacles. Nanoparticles must avoid nonspecific interactions with healthy cells and in vivo compartments to circumvent these barriers. Since in vivo interactions of nanoparticles are mainly dependent on surface properties of nanoparticles, efficient control on surface constituents is necessary for the determination of nanoparticles’ fate in the body.

Areas covered

In this review, the surface-modified polymeric nanoparticles and their utilization in cancer treatment were elaborated. First, the interaction of nanoparticles with numerous in vivo barriers was highlighted. Second, different strategies to overcome these obstacles were described. Third, some inspiring examples of surface-modified nanoparticles were presented. Later, fabrication and characterization methods of surface-modified nanoparticles were discussed. Finally, the applications of these nanoparticles in different routes of treatments were explored.

Expert opinion

Surface modification of anticancer drug-loaded polymeric nanoparticles can enhance the efficacy, selective targeting, and biodistribution of the anticancer drug at the tumor site.

中文翻译：

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表面改性的聚合物纳米颗粒，用于将药物递送至癌细胞。

摘要

介绍

聚合物纳米颗粒作为药物有效载荷的利用已在癌症治疗中广泛流行。然而，这些纳米载体的精确分布受到各种生理和细胞障碍的限制。纳米粒子必须避免与健康细胞和体内隔室的非特异性相互作用，以规避这些障碍。由于纳米粒子的体内相互作用主要取决于纳米粒子的表面特性，因此有效控制表面成分对于确定体内纳米粒子的命运是必要的。

覆盖区域

在这篇综述中，阐述了表面改性的聚合物纳米粒子及其在癌症治疗中的利用。首先，突出了纳米粒子与众多体内屏障的相互作用。其次，描述了克服这些障碍的不同策略。第三，介绍了一些鼓舞人心的表面改性纳米粒子的例子。随后，讨论了表面改性纳米粒子的制备和表征方法。最后，探讨了这些纳米粒子在不同治疗途径中的应用。

专家意见

载有抗癌药的聚合物纳米颗粒的表面修饰可增强抗癌药在肿瘤部位的功效，选择性靶向和生物分布。