Activities of cefiderocol under simulated human plasma concentrations at the recommended dosing regimen of 2 g every 8 h with a 3-h infusion were evaluated using an in vitro chemostat model. Against a total of 6 meropenem-resistant Gram-negative strains with cefiderocol MICs of 0.5 to 4 μg/ml, including metallo-β-lactamase producers and carbapenem-resistant Acinetobacter baumannii, cefiderocol treatment showed a bactericidal effect within 8 h and sustained efficacy with no marked bacterial regrowth over 24 h.

中文翻译：

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模拟人血浆浓度的头孢地洛尔在体外化学恒热模型中对耐碳青霉烯类革兰氏阴性杆菌的活性。

使用体外化学恒温器模型评估了在模拟人血浆浓度下，每8小时2 g的推荐剂量方案，每3 h注射一次时头孢洛尔的活性。对于包括金属β-内酰胺酶生产者和耐碳青霉烯的鲍曼不动杆菌在内的总共6株头孢地洛醇MIC为0.5至4μg/ ml的耐美罗培南的革兰氏阴性菌株，头孢地洛尔治疗在8小时内显示出杀菌作用，并具有持续的疗效在24小时内没有明显的细菌再生长。