The sodium hypochlorite (NaOCl) strong cytotoxicity and the potential to cause accidents by extrusion are the main concerns about its use as root canal irrigant. NaOCl gel has been proposed to improve safety. This research aimed to develop and characterize a NaOCl gel formulation using a surfactant. Seven gels with 2.5% NaOCl were produced using sodium lauryl ether sulfate (SLES) with concentrations between 2.0% and 5.0%. The gels were characterized by pH, surface tension, wettability, viscosity, Fourier transform infrared spectroscopy (FT‐IR), bactericidal potential, and organic tissue dissolution. The gels pH which concentration was between 2.0% and 4.5% did not differ significantly from the 2.5% NaOCl solution. The surfactant reduced surface tension by more than 50% in all the gels, without statistical difference between them. Wettability decreased as SLES percentage in NaOCl formulation increased. The SLES addition provided viscous formulations. FTIR analysis showed intermolecular interactions between the SLES and NaOCl. Only 3.0% and 3.5% gels showed significantly reduced bactericidal activity (15 ± 0.7). All gels presented significantly reduced organic matter dissolution rate compared to the NaOCl solution (>56.33 ± 2.88 min). SLES is a surfactant compatible with NaOCl and promising viscosifying agent.

中文翻译：

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牙髓用次氯酸钠凝胶的研制与表征

次氯酸钠（NaOCl）具有很强的细胞毒性，并可能因挤压而引起事故，这是将其用作根管冲洗剂的主要问题。已提出NaOCl凝胶以提高安全性。这项研究旨在开发和表征使用表面活性剂的NaOCl凝胶制剂。使用月桂基醚硫酸钠（SLES）生产浓度为2.0％至5.0％的七种含2.5％NaOCl的凝胶。凝胶的特征在于pH，表面张力，润湿性，粘度，傅立叶变换红外光谱（FT-IR），杀菌潜力和有机组织溶解。浓度在2.0％至4.5％之间的凝胶pH与2.5％NaOCl溶液无明显差异。在所有凝胶中，表面活性剂均使表面张力降低了50％以上，而凝胶之间没有统计学差异。随着NaOCl配方中SLES百分比的增加，润湿性降低。SLES的添加提供了粘性配方。FTIR分析表明SLES和NaOCl之间存在分子间的相互作用。只有3.0％和3.5％的凝胶显示出明显降低的杀菌活性（15±0.7）。与NaOCl溶液相比，所有凝胶均表现出明显降低的有机物溶解速率（> 56.33±2.88分钟）。SLES是与NaOCl相容的表面活性剂和有前途的增粘剂。与NaOCl溶液相比，所有凝胶均表现出明显降低的有机物溶解速率（> 56.33±2.88分钟）。SLES是与NaOCl相容的表面活性剂和有前途的增粘剂。与NaOCl溶液相比，所有凝胶均表现出明显降低的有机物溶解速率（> 56.33±2.88分钟）。SLES是与NaOCl相容的表面活性剂和有前途的增粘剂。