当前位置: X-MOL 学术Chem. Asian J. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Unified Total Synthesis of (-)-Enigmazole A and (-)-15-O-Methylenigmazole A.
Chemistry - An Asian Journal ( IF 4.1 ) Pub Date : 2020-09-09 , DOI: 10.1002/asia.202001015
Keisuke Sakurai 1 , Keita Sakamoto 1, 2 , Makoto Sasaki 1 , Haruhiko Fuwa 2
Affiliation  

The total synthesis of cytotoxic marine phosphomacrolides, (−)‐enigmazole A and (−)‐15‐O‐methylenigmazole A, is described in detail. The 2,6‐cis‐substituted tetrahydropyran ring was efficiently elaborated by using a tandem olefin cross‐metathesis/intramolecular oxa‐Michael addition reaction. The 18‐membered macrolactone skeleton was forged via a Au‐catalyzed propargylic benzoate rearrangement/macrocyclic ring‐closing metathesis sequence. Late‐stage diversification of a common intermediate enabled unified total synthesis of (−)‐enigmazole A and (−)‐15‐O‐methylenigmazole A.

中文翻译:

(-)-Enigmazole A和(-)-15-O-Methylenigmazole A的统一全合成。

详细描述了细胞毒性海洋磷化氢的总合成(-)-烯乙唑A和(-)-15- O-甲基-烯乙唑A. 通过使用串联烯烃交叉复分解/分子内氧杂-Michael加成反应可有效地修饰2,6-顺式-取代的四氢吡喃环。18元大内酯骨架是通过Au催化的炔丙基苯甲酸酯重排/大环闭合复分解序列锻造的。通用中间体的后期分散化实现了(-)-恩格唑A和(-)-15- O-甲基-乙炔A的统一总合成。
更新日期:2020-11-04
down
wechat
bug