Complex, functionally embellished natural products embodying diverse, oxygen rich furofuranone fragments like furo[3,4‐c]furanone, furo[2,3‐b]furanone, furo[3,4‐b]furan‐2(3H)‐one, furo[3,4‐b]furan‐4(2H)‐one and furo[3,4‐b]furan‐6(4H)‐one as the key motif and displaying wide range of biological activities such as anti‐cancer, anti‐HIV, anti‐microbial activities, etc., continue to draw considerable traction towards targeted synthesis, methodolgical developments as well as medicinal chemistry guided efforts. The challenging and tempting combination of complexity laden architecture and varied bioactivity profile, among the variegated furofuranone natural products has led to intense synthetic activity in the arena in recent years and culminated in the total synthesis of structurally diverse family of bioactive metabolites such as gracilioethers, syringolides, degraded spongianes etc. While comprehensively recounting the attainments in the total syntheses of furofuranone natural products in the past two decades (in the 21st century), this review attempts to identify the key tactics deployed in each synthetic campaign. This topical review aims at drawing and sustaining the interest of synthetic chemistry community in undertaking further creative pursuits towards this rich and enticing family of natural products while concurrently exploring the utility driven diversity space around them.

中文翻译：

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包含不同的呋喃呋喃酮基序的天然产物的全合成进展：新的千年更新

复杂的，功能齐全的天然产物，包含各种富氧的呋喃呋喃酮片段，例如呋喃[3,4 -c ]呋喃酮，呋喃[2,3- b ]呋喃酮，呋喃[3,4 -b ]呋喃-2（3H）- ，furo [3,4 -b ] furan-4（2H）-one和furo [3,4 -b呋喃-6（4H）-one作为主要基序并展现出广泛的生物活性，例如抗癌，抗艾滋病毒，抗微生物活性等，继续在目标合成，方法学发展等方面吸引相当大的吸引力。以及药物化学指导的努力。杂色的呋喃呋喃酮天然产物中复杂的结构和变化的生物活性谱图具有挑战性和诱人的组合，导致近年来在竞技场上产生了强烈的合成活性，并最终完成了结构多样的生物活性代谢物家族的合成，如鹅油醚，丁香油精。 ，降解的海绵等。虽然全面回顾了过去20年（在21世纪）呋喃呋喃酮天然产物的合成总量，这次审查试图确定在每个综合战役中部署的关键策略。本主题回顾旨在吸引和维持合成化学界对这个丰富而诱人的天然产品系列进行进一步的创造性追求的兴趣，同时探索由实用程序驱动的围绕它们的多样性空间。